The reason I bring up thermodynamics is that there seems to be a strong correlation between lifespan and energy intensity of animal life. The more energy intensive lifestyle an animal lives, the shorter it lives. So there is a fundamental thermodynamic constraint on animal life which is systematic to everything living on this planet. The how and why of breaking that has barely ben approached, which means I think the best we can do in the short term is make human lifespans 110 - 125 years as a matter of course. Which, in good health and mental fitness, I would be perfectly happy with, myself.
This is a very simplistic approximation that is a catch-all for many biological and non-biological variables. For example, staying within the mammalian life to discount some other variables, famously inactive sloths live 30-40 years in captivity, slightly less in the wild.
It's pretty similar to many bears, with which they are biologically related.
And then there are, say, elephants, with lifespans similar to upper end for humans. Pretty long one by any standard...
Compare that to the giraffe, another very large herbivore mammal with similar "life style" to elephants - but they hardly even reach 30!
Among mammals, the record lifespan owners are some species of whales, getting somewhere into 2 century range, details aren't too clear due to the rarity and timescale involved.
Outside of mammals, there is quite a bunch of reptiles that beat the 200 year mark, and the absolute verified record among large, reasonably complex animals is a
nearly 400 year old shark, though it's metabolism is fairly slow by shark standards at least.
So, metabolism is a major factor... But as these examples show, far from the only one.
And then there is this particular outlier that's of scientific interest:
en.wikipedia.org
The capability of biological immortality with no maximum lifespan makes
T. dohrnii an important target of basic biological,
aging and
pharmaceutical research.
With human aging, there are the artificial interventions of medical science to throw into the mix, making significant changes possible One thing is to keep the brain functioning reasonably well, which many theorize could, barring issues like dementia appearing, which many don't live nearly long enough to appear and which can be controlled to a degree already. The other area is to keep the brain's "support system" functioning, failure of which is the cause of vast majority of old age deaths. That's a lot of opportunities for improvement, including with more heavy handed interventions like organ replacement. One thing to note that only once advancements in this area happen, it will become even possible to study the aging of brains in 150 or 200 year humans, and see how that goes and what are the possibilities for improvement there.