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No,but there would be more primarchs,like primarch of Alexandria.Which would be practically free from both Rome and Constamtinopole to do as they please,even if formally they all would be belonging to one Church. And probably few Ethiopian-like churches,too.

No islam - it mean zoroastrian Persia.And considering that most christain there belonged to eastern churches/no orthodox / their chrystianity would be probably more like Ethiopia then Byzantinum. Another change - land road to India would be open.Probably nobody would bother with sea road...