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Somewhat. American Blacks have some genetic traits for disease resistance (notably sickle cells, which are good at limiting malaria but bad at everything else), not as many as Carribbean Blacks but significantly more then Whites have. Without any pressure from White settlers, I can't see any...

OTL, the criollo-dominated Republic of the Yucatan tried to annex itself into the U.S. in 1848, and the bill to accept this failed in the Senate by two votes. Had it succeeded, the U.S. would've inherited the Yucatec Caste War, an ongoing bloodbath of an insurgency that pitted the criollos and...