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Ah true I forgot the OP referred to settlers, i.e. it becoming a predominantly settler colony with the bulk of the population being of European descent. :oops:

There were, as there were in the American tropics after old world diseases reached there and made them similarly lethal. The question was did the rewards of trade in those regions in Africa make the risks worthwhile to many? [IIRC it was a similar although possibly somewhat less dangerous...

Well they knew there was definitely a problem, despite not knowing why. For instance malaria getting its name because they thought the illness was because of 'bad air'. However for a long while the tropical parts of Africa were known as the 'White man's graveyard' and people only went there...