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Mass Effect and the Cthulhu Mythos. The Reapers work really well as Elder God substitutes, though part of this is that Mass Effect just cribbed from Lovecraft. There's a pretty good fusion where they use the Mass effect characters in an All human age of sail AU, putting Shepard as the head of a...

One Piece and Naruto. There is a really good fic that fuses the two by making the Naruto World basically an island in the Grand Line.