The Internet of Bodies and the Plot to Enslave Mankind

Iconoclast

Perpetually Angry
Obozny
When I was a kid, I was dimly aware of the Internet of Things. Telecom researchers were always going on about it back in the mid-2000s, and it started being adopted as an actual principle around the time smartphones showed up.

People were talking about cramming sensors and Wi-Fi and Bluetooth chips in everything, from picture frames to flower pots. I always felt that this was wasteful, pointless, and excessive. Just a bunch of new things in the house where you have to change out AAAs or button cells every few months to keep it working. Who the hell was buying those stupid refrigerators with screens in 'em and using them to watch football while they microwaved a hot pocket? Basically, IoT is pure bullshit. I always thought of it as a solution in search of a problem. It seemed so gimmicky, like a ham-fisted attempt to carve out a niche for something that simply didn't need to exist.

In retrospect, I am starting to believe that IoT was a trojan horse for something else entirely: the Internet of Bodies. That is, IoT where you are the thing.

They call it by many names. Internet of Bodies (IoB), Internet of Bio-Nano Things (IoBNT), Intra-Body Nano-Networks, In-Body Communication, Bionanotechnology, Biodigital Convergence, and so on and so forth. This is because the concept is so new that they haven't decided on harmonized jargon for it. A bunch of different scientists working on different branches of IoB came up with their own terminology, so we have like half a dozen different acronyms for the same thing. For simplicity's sake, I'll refer to implanted nanotech and cloud-enabled wearable medical devices primarily as IoB, the over-arching category that includes the other implementations of the same idea, with Bionanotechnology as the method.

There was a book published in 1946 by Oliver L. Reiser entitled The World Sensorium. To quote from the chapter, Birthing of the World Brain:

The analogy of society to an organism has frequently been employed, often for the purpose of supporting quite contradictory social theories. St. Paul, Frances Bacon, Herbert Spencer, Oswald Spengler, and many others have drawn diverse implications from the organismic analogy. The use to which the theory is put in the doctrine of scientific humanism is based on this one proposition: in previous uses of the analogy the assumption is made that society is an organism, whereas in the present view we suppose that society must become like an organism. This poses the question, if society is not yet an organism, but can in the future develop into one, what kind of social organism do we humans want to create?
In briefest terms, the answer of planetary democracy to this question is as follows: we need to create one with a sensorium, a central nervous system, with a world cortex for over-all planning and synthesis.

In this book, in the same chapter, there is also a quote from Julian Huxley, the brother of Aldous Huxley (the author of Brave New World, naturally), which reads:

"Before humanity can obtain on the collective level that degree of foresight, control and flexibility which on the biological level is at the disposal of human individuals, it must multiply at least tenfold, perhaps fiftyfold, the proportion of individuals and organizations devoted to obtaining information, to planning, correlation and the flexible control of execution. The chief increases are needed in respect of correlation and planning and of social self-consciousness ... In respect of planning and correlation, we can dimly perceive that some large single organization must be superposed on the more primitive system of separate government departments and other single-function organizations; and that this, like the cerebral cortex, must be at one and the same time unified and functionally specialized."

Likewise, H.G. Wells held numerous talks and wrote essays on the thirties on the need for a "World Brain".


Humanity had all of the information necessary to live together in peace and harmony, Wells told his audiences; the trouble was that this information existed in a disorganized, dispersed state, and most people didn't have access to it. They certainly didn't have access to the most up-to-date information, and with the rapid pace of technological advancement in the early 20th century—leading to cars, planes, and especially radio—information needed updating constantly.

If only everyone had the same education, the same knowledge, the same understanding of what was important, his thinking went—if only everyone knew the truth—it was inevitable that we'd form a productive, peaceful, global society. Conversely, without his educational reforms, Wells felt there was no way we'd transcend the mess of grubby, meaningless insularities that is our civilization.

Wells was promoting a Permanent World Encyclopedia to collate, standardize, assess, and continually revise the bulk of human knowledge. He wanted knowledge and its dissemination to be centralized—"a World Brain which will replace our multitude of unco-ordinated ganglia... a memory and a perception of current reality for the entire human race."

To a certain extent, the internet has fulfilled that promise. Nearly 60% of the world's population has internet access in some form or another, allowing for instantaneous global collaboration, the sharing of knowledge and news, et cetera. It has brought us closer together in a way that no other technology has.

It has also sown seeds of division. As people started debating each other more often about their most strongly held personal beliefs that form the basis of their worldviews, many have retreated into echo chambers forming islands of serenity where all argument about anything beyond the most trivial of matters is avoided entirely.

These days, it's difficult to find someone willing to wade into a forum where most of the members hold an opposing viewpoint. Why bother, when one can always get a dopamine hit of approval from preaching to the choir? Even the moderators join in on enforcing echo chambers, deleting or suppressing posts that lie too far outside a forum's Overton Window. Try going on Sufficient Velocity and saying that the gas attacks in Syria were faked. I did that, once. I had a mod tell me, straight-up, "You can't say that the gas attacks in Syria were faked". It wasn't even up for debate. They just flatly denied it was possible, in spite of the leaked conflicting report that showed that the cylinders they found were likely hand-placed, and that the chlorine concentrations in the air were in the range of a couple parts per billion; no more than what you'd get from people doing their laundry.

So, we have a World Brain, but it's a partial one. It's not complete. It's not the damn-near-hive-mind that Julian Huxley and H.G. Wells envisioned nearly a century ago. Far from it. It's an engine of social tension, with disparate levels of access and incomplete coverage. It's like the unfinished Akulakhan under Red Mountain in Morrowind. The internet is an incomplete god.

There was always one final step to completing it, and that final step was connecting everyone's minds and bodies directly to the internet.

Every time I bring this up, people think I'm joking. There's no way. This is just some Black Mirror nonsense. They can't actually be doing this, right?

Wrong. Not only are they doing this, they're doing it right under everyone's noses. Everything about it is published out in the open, in plain view. Two of the leading figures in this field are Ian F. Akyildiz and Josep M. Jornet:


6G and beyond will fulfill the requirements of a fully connected world and provide ubiquitous wireless connectivity for all. Transformative solutions are expected to drive the surge for accommodating a rapidly growing number of intelligent devices and services. Major technological breakthroughs to achieve connectivity goals within 6G include: (i) a network operating at the THz band with much wider spectrum resources, (ii) intelligent communication environments that enable a wireless propagation environment with active signal transmission and reception, (iii) pervasive artificial intelligence, (iv) large-scale network automation, (v) an all-spectrum reconfigurable front-end for dynamic spectrum access, (vi) ambient backscatter communications for energy savings, (vii) the Internet of Space Things enabled by CubeSats and UAVs, and (viii) cell-free massive MIMO communication networks. In this roadmap paper, use cases for these enabling techniques as well as recent advancements on related topics are highlighted, and open problems with possible solutions are discussed, followed by a development timeline outlining the worldwide efforts in the realization of 6G. Going beyond 6G, promising early-stage technologies such as the Internet of NanoThings, the Internet of BioNanoThings, and quantum communications, which are expected to have a far-reaching impact on wireless communications, have also been discussed at length in this paper.

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B. Internet of BioNanoThings for Health Applications

Highly relevant to IoNT, with its unique characteristics and applications, is the concept of the Internet of BioNanoThings (IoBNT). First introduced in 2015, the IoBNT has garnered significant traction in its efforts to synergistically combine telecommunications with healthcare solutions [174]. The IoBNT is a network of molecules which can communicate with each other. The types of molecular communications include artificial cells which act as gateways to translate between different molecule types, or a bio-cyber interface which can convert molecular signals to electrical ones and transmit to external devices for further processing [175].

In applications relating to human healthcare, the IoBNT harbors many unique challenges and opportunities. First, the interdisciplinary research on both communications and data analytics can greatly facilitate the modeling of biological processes, including cancer cell formations and Alzheimer's disease, and further design effective control measures for such diseases. Second, even though expressions of genetic codes at the cell- and organ-level can vary remarkably, in a manner analogous to various types of data applications in wireless networks, communication models can be developed and exploited to conceive a generally applicable health information framework. Third, the holistic network architecture envisioned in the IoBNT will integrate components at heterogeneous levels including within cells and among tissues, organs, as well as systems, before eventually connecting to the outside Internet for physicians to perform metric evaluations and propose treatment plans accordingly. However, healthcare solutions that are to be realized in such complicated biological and molecular environments should be built upon a solid understanding of the physics behind molecular communication and advanced statistical analysis tools in order to unveil the principles behind the seemingly random molecular movement.









A few key things to keep in mind:


How did I find out about these two researchers and their work? Simple. I asked ChatGPT using the GPT-4 model, and without hesitation, it told me. Everything.

Part 1:
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Part 2:
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A few years ago, Charles Lieber was indicted by the DOJ for double-dipping and taking money from China's Thousand Talents Plan against the terms of his DOD grants. He was collaborating with the Wuhan University of Technology and taking great big sacks of cash from China, and he was also engaging in tax evasion.


According to court documents, since 2008, Dr. Lieber who has served as the Principal Investigator of the Lieber Research Group at Harvard University, which specialized in the area of nanoscience, has received more than $15,000,000 in grant funding from the National Institutes of Health (NIH) and Department of Defense (DOD). These grants require the disclosure of significant foreign financial conflicts of interest, including financial support from foreign governments or foreign entities. Unbeknownst to Harvard University beginning in 2011, Lieber became a "Strategic Scientist" at Wuhan University of Technology (WUT) in China and was a contractual participant in China's Thousand Talents Plan from in or about 2012 to 2017. China's Thousand Talents Plan is one of the most prominent Chinese Talent recruit plans that are designed to attract, recruit, and cultivate high-level scientific talent in furtherance of China's scientific development, economic prosperity and national security. These talent programs seek to lure Chinese overseas talent and foreign experts to bring their knowledge and experience to China and reward individuals for stealing proprietary information. Under the terms of Lieber's three-year Thousand Talents contract, WUT paid Lieber $50,000 USD per month, living expenses of up to 1,000,000 Chinese Yuan (approximately $158,000 USD at the time) and awarded him more than $1.5 million to establish a research lab at WUT. In return, Lieber was obligated to work for WUT "not less than nine months a year" by "declaring international cooperation projects, cultivating young teachers and Ph.D. students, organizing international conference, applying for patents and publishing articles in the name of" WUT.

The complaint alleges that in 2018 and 2019, Lieber lied about his involvement in the Thousand Talents Plan and affiliation with WUT. On or about, April 24, 2018, during an interview with investigators, Lieber stated that he was never asked to participate in the Thousand Talents Program, but he "wasn't sure" how China categorized him. In November 2018, NIH inquired of Harvard whether Lieber had failed to disclose his then-suspected relationship with WUT and China's Thousand Talents Plan. Lieber caused Harvard to falsely tell NIH that Lieber "had no formal association with WUT" after 2012, that "WUT continued to falsely exaggerate" his involvement with WUT in subsequent years, and that Lieber "is not and has never been a participant in" China's Thousand Talents Plan.

Supposedly, he was working on silicon nanowire batteries for the WUT.


In fact, one U.S. nanoscientist and former student of Lieber's says: "I have never seen Charlie working on batteries or nanowire batteries." (The scientist asked that their name not be used because of the sensitivity surrounding Lieber's case.)

There's just one problem. None of his papers involve batteries in any way, shape or form. All of his research involves bionanotechnology.


For instance, here's an incredibly creepy paper about having neurons internalize silicon nanowires by coating them with HIV TAT peptides, potentially using them as teeny tiny biosensors residing in the cytosol alongside all the little organelles inside those cells:


Semiconductor nanowire (NW) devices that can address intracellular electrophysiological events with high sensitivity and spatial resolution are emerging as key tools in nanobioelectronics. Intracellular delivery of NWs without compromising cellular integrity and metabolic activity has, however, proven difficult without external mechanical forces or electrical pulses. Here, we introduce a biomimetic approach in which a cell penetrating peptide, the trans-activating transcriptional activator (TAT) from human immunodeficiency virus 1, is linked to the surface of Si NWs to facilitate spontaneous internalization of NWs into primary neuronal cells. Confocal microscopy imaging studies at fixed time points demonstrate that TAT-conjugated NWs (TATNWs) are fully internalized into mouse hippocampal neurons, and quantitative image analyses reveal an ca. 15% internalization efficiency. In addition, live cell dynamic imaging of NW internalization shows that NW penetration begins within 10−20 min after binding to the membrane and that NWs become fully internalized within 30−40 min. The generality of cell penetrating peptide modification method is further demonstrated by internalization of TAT-NWs into primary dorsal root ganglion (DRG) neurons.

Yes, I'm sure this sort of research is very useful for building batteries. That's why he had gobs of DARPA, AFOSR, and ONR funding. Batteries. Right. :rolleyes:
 
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Iconoclast

Perpetually Angry
Obozny
Surely these are all just innocent scientific investigations of the underlying physics, though, right? They can't actually be contemplating incorporating this into real infrastructure, can they?

On the contrary. They are already actively implementing these ideas.










The blending of human biology with machinery at the nano-scale is a cornerstone of Klaus Schwab's Fourth Industrial Revolution, and his books explicitly reference both DARPA's BRAIN Initiative in specific and bionanotechnology in general, and he has been on record numerous times saying that the "digital and biological realms will merge together" and that people will become man-machine hybrids at the molecular level.

This technology is meant to be integrated into Smart City infrastructure. Why have there been so many attacks on farmers and rural-dwellers, lately? Train derailments with toxic chemicals in the US, or crackdowns on farmers in the Netherlands? Simple. The ruling class want to seize all the pristine rural land through eminent domain, re-privatize it and establish themselves as rentier-overlords controlling it, force people into cities, and warehouse them there, under the influence of a Smart Grid.

They want perfect, top-down, cybernetic tracking and control of human movements, and I mean that in the classical sense of systems cybernetics being a method of implementing control loops, not necessarily in the sense of humans becoming "cyborgs", but it technically involves both.

This technology is a weapon. And I mean that in the sense that people have stood up on stage in front of cadets at West Point and explicitly described these technologies and their immense weaponization potential, and how they could be used to create super-intelligence-officers with photographic memory, turn soldiers into emotionless killing machines, or even influence dissident leaders by driving them absolutely batshit insane to the point that all their followers abandon them:





They are already discussing the use of bionanotechnology as a means of "bloodless warfare", essentially as a new generation of chemical weapons not covered by existing regulations or treaties, because of their highly subtle incapacitation effect. The goal is not to kill or maim people, but to influence their behavior, which, ultimately, is far more sinister and dishonest than just straight-up killing someone. Some people have seen the writing on the wall, but their warnings go unheeded:


In the same vein, the scarcity of publicly available information about military research into biotechnology might fuel public distrust of valuable and well-intended work. It is clear, for example, that research into preventing, identifying, and treating infectious diseases by various militaries around the world will continue to provide broader spin-off benefits—but publics in some states might be unsure why military rather than public health institutions lead such work.

A path toward addressing these concerns has already been established by the synthetic biology community—especially in terms of its preemptive engagement with the security concerns that scientists entertain. However, even in this arena there has been a hesitance to address the issue of militarization.

The guys behind all of this are friggin' Death Eaters and they want the friggin' Imperius curse to be a part of their toolbox. They want the power to effortlessly turn friend against friend, neighbor against neighbor, without even needing to use the traditional methods of astroturfing or propaganda. Does that sound like hyperbole? Comical exaggeration, maybe?


As part of its Cognitive Domain of Operations, China has defined "Military Brain Science (MBS) as a cutting-edge innovative science that uses potential military application as the guidance. It can bring a series of fundamental changes to the concept of combat and combat methods, creating a whole new "brain war" combat style and redefining the battlefield."49 The pursuit of advances in the field of MBS is likely to provide cutting edge advances to China.The development of MBS by China benefits from a multidisciplinary approach between human sciences, medicine, anthropology, psychology etc. and also benefits from "civil" advances in the field, civilian research benefiting military research by design.

A cognitive attack is not a threat that can be countered in the air, on land, at sea, in cyberspace, or in space. Rather, it may well be happening in any or all of these domains, for one simple reason: humans are the contested domain. As previously demonstrated, the human is very often the main vulnerability and it should be acknowledged in order to protect NATO's human capital but also to be able to benefit from our adversaries's vulnerabilities.

Imagine the kind of psychopathy it takes for someone to write a white paper that unironically includes the words "humans are the contested domain".

If people can't see what's happening here, it's because they're not paying any attention. Like, at all. Instead of paying people a living wage and letting us live comfortable middle-class lifestyles, these finger-steepling NWO maniacs want to turn us into Crichton's fucking Terminal Man, impose artificial bliss upon us, stuff us in concrete commieblocks and feed us cricket paste.

This problem supersedes literally all other political concerns. Everyone is being distracted with domestic policy kabuki theater about abortion and gay people, while, behind the scenes, these rat bastards want to implement a cashless transaction system, digital ID, social credit scores, and compulsory implanted nanotechnology as a requirement to be able to access literally any fucking part of society.

At best, this is surveillance capitalism on steroids. They'll use this tech to harvest people's brain and body data, feed their biometrics into machine learning algorithms, and use it to predict human behavior and front-run markets. At worst, it's a form of tyranny that has never been seen before in recorded history.

Our fundamental freedoms and inalienable rights are under attack like never before. Our autonomy, privacy, dignity, and humanity are being savagely stripped away. This is the story of the century, and the journos aren't touching it with a barge pole.
 
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Iconoclast

Perpetually Angry
Obozny
Jesus Christ. Just when you thought things could not get worse.

Why was I cursed to be born into this era?
Read the comments to these two vids (after watching them, of course):



I love that nearly 100% of the comments see the danger here, and oppose this insanity.
Surprised that TED didn't turn off the comments here (perhaps they will later?).

This is of course a dystopian nightmare in the making. There is a dual-use purpose for every technology, the "innovators" always present the best use case, while downplaying any potential negatives.



This is absolutely terrifying and its adoption shouldn't even be a discussion. Outlaw it immediately!
All these people in that room, and especially this speaker, need to be locked up for crimes against humanity and never released. Her speaking like what she's talking about is 'ok' is absolutely terrifying and the fact that she's speaking about it to people who are equally disturbing, should be questioned extensively for years, until we figure out why they are the way they are, so we don't create the same environment, so we don't have any more people like this.

People are very perturbed by this stuff, as they should be. Why do you think YouTube got rid of dislikes? It's because they know vids like this will get ratioed into oblivion, but they want people to form positive opinions about tyrannical nonsense.

I have an extension that returns dislikes. That TEDx talk stands at 160 likes, 1000 dislikes, and the one with Nita Farahany grinning like an idiot while describing the most dystopian garbage imaginable is at 576 likes, 3900 dislikes. Nobody wants this crap from these Davos cultists. Almost everyone normal who's exposed to it pretty much instantly reacts with overwhelming disgust.

This stuff needs widespread exposure. Now.
 

Iconoclast

Perpetually Angry
Obozny
An entire generation is addicted to their smartphones and random cheap dopamine hits. They will welcome this.

Either openly or through fear.
Indeed. They will sell it as a convenience. No need to carry a wallet around anymore. Your body is your ID. Having a medical emergency? Don't worry, your internal organs will dial 911 for you. Typing with your thumbs on your phone too difficult? We'll just have an implant read your mind and text will magically pop onto your screen. Keep losing your earbuds? We'll pipe sound directly into your auditory cortex.

BCIs will be both a means of mass surveillance and detecting and eliminating wrongthink at the source, and entertainment devices, and a way to treat blindness and paralysis. They'll hawk these things as consumer gadgets and medical implants, while also giving the NSA, the CIA, the GCHQ, and other alphabet agencies back doors directly into people's bodies and letting trillion-dollar multinational corporations harvest biometric data and run AI algorithms on it in huge data centers to extract population-scale metrics from people.
 

Rocinante

Russian Bot
Founder
An entire generation is addicted to their smartphones and random cheap dopamine hits. They will welcome this.

Either openly or through fear.
They'll do it openly.

If these things are giving augmented humans an edge that non augmented humans don't have, augmented humans will be superior and outcompete the non augmented.

So to compete in society, most will need to become augmented. There will of course be holdouts, but the majority will do it willingly.
 

LordsFire

Internet Wizard
They'll do it openly.

If these things are giving augmented humans an edge that non augmented humans don't have, augmented humans will be superior and outcompete the non augmented.

So to compete in society, most will need to become augmented. There will of course be holdouts, but the majority will do it willingly.

Cybernetic augmentation is still the realm of pure fiction, and likely will be for decades to come.

If a mind-machine interface can be figured out that doesn't have massive drawbacks, that in particular will change, but any sort of strength, speed, durability, etc, 'enhancement' will continue to be outperformed by non-invasive technology you can equip.

Shadowrun, Cyberpunk, etc, are 'soft' science fiction and will remain so.

People just generally do not understand how incredibly well-engineered a machine the human body is.
 

DarthOne

☦️
Cybernetic augmentation is still the realm of pure fiction, and likely will be for decades to come.

If a mind-machine interface can be figured out that doesn't have massive drawbacks, that in particular will change, but any sort of strength, speed, durability, etc, 'enhancement' will continue to be outperformed by non-invasive technology you can equip.

Shadowrun, Cyberpunk, etc, are 'soft' science fiction and will remain so.

People just generally do not understand how incredibly well-engineered a machine the human body is.
Maybe so. but I say its high time we start pushing HARD to outlaw this stuff worldwide. Preempt this shit before it takes off further. As in 'any nation that gets caught pursuing this gets a faceful of a can of instant sunshine'.
 

LordsFire

Internet Wizard
Maybe so. but I say its high time we start pushing HARD to outlaw this stuff worldwide. Preempt this shit before it takes off further. As in 'any nation that gets caught pursuing this gets a faceful of a can of instant sunshine'.

Why?

If they want to throw away millions to billions on research that would be far more productive on developing something that's actually feasible, like powered armor, why not let them?
 

Morphic Tide

Well-known member
People just generally do not understand how incredibly well-engineered a machine the human body is.
More that it's "good enough" for a staggering variety of tasks and a nightmarish pain in the ass to interface with. Genetics is a nigh-incomprehensible clusterfuck of barely-stable back-and-forth with a nasty habit of collapsing unpredictably when you change anything and properly converting electrochemical nervous system signals to digital formats is unsolved.

If it weren't for those unexpected roadblocks to improving people (the concept of "a gene" turned out to be fuzzy bullshit), it'd have happened very shortly after it started being predicted. Because we've built up a very long list of very obvious improvements, some of which are well inside current genetic engineering if GMO people were allowed like removing the possibility of scurvy.
 

LordsFire

Internet Wizard
Because I'm not willing to gamble that they somehow find a way. You forget how much of our modern technology would have once been seen as 'impossible' or 'science fiction'.

Some things, the more we understand them, the more difficult they prove to be.

For example, Star Trek in the 1960's predicted motion-sensitive doors, and some engineers watching the show said 'we could do that right now,' and so they did. It also predicted easy space travel by the 1990's, but that absolutely did not happen.

It sort of predicted cell phones, though hardly was the only sci-fi to do so, but even 90's Star Trek failed to predict how quickly wireless networking would develop. Common and easy wi-fi came before functional voice-controlled computers, which had been predicted by the 60's trek.

Different concepts prove to have different difficulty curves, and cybernetics are one of those things that as we get closer to some degree of ability to replace lost functionality, it becomes more and more clear that increasing functionality is insanely difficult.

Every bit of technology needed to make it possible to actually have a 'cybernetic supersoldier body' would mean that you can have a regular human body inside of a suit of power armor at a fraction of the cost, both monetary and human.
 

DarthOne

☦️
Some things, the more we understand them, the more difficult they prove to be.

For example, Star Trek in the 1960's predicted motion-sensitive doors, and some engineers watching the show said 'we could do that right now,' and so they did. It also predicted easy space travel by the 1990's, but that absolutely did not happen.

It sort of predicted cell phones, though hardly was the only sci-fi to do so, but even 90's Star Trek failed to predict how quickly wireless networking would develop. Common and easy wi-fi came before functional voice-controlled computers, which had been predicted by the 60's trek.

Different concepts prove to have different difficulty curves, and cybernetics are one of those things that as we get closer to some degree of ability to replace lost functionality, it becomes more and more clear that increasing functionality is insanely difficult.

Every bit of technology needed to make it possible to actually have a 'cybernetic supersoldier body' would mean that you can have a regular human body inside of a suit of power armor at a fraction of the cost, both monetary and human.
That’s nice and all but my position remains the same.
 
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Iconoclast

Perpetually Angry
Obozny
Cybernetic augmentation is still the realm of pure fiction, and likely will be for decades to come.

If a mind-machine interface can be figured out that doesn't have massive drawbacks, that in particular will change, but any sort of strength, speed, durability, etc, 'enhancement' will continue to be outperformed by non-invasive technology you can equip.

Shadowrun, Cyberpunk, etc, are 'soft' science fiction and will remain so.

People just generally do not understand how incredibly well-engineered a machine the human body is.
People had the wrong idea about cyborgs. Everyone has this misconception of cyborgs as people with glowing artificial eyes and their arms and legs sawn off and replaced with metal limbs, and it has literally nothing to do with any of the research into 'borgizing people that I've seen.

What they are seriously investigating right now is molecular nanotechnology that imitates and interfaces with biological systems.








Where this leads is less cyberpunk and more biopunk. Want a better bomb sniffer than a sniffer dog? Culture dog olfactory neurons with a restricted range of chemoreceptors fine-tuned to pick up traces of explosive residue in a petri dish and fill them full of nanosensors so you know when and how they spike. Want to make a supersoldier? Don't cut his limbs off and replace them with hydraulics. Instead, optimize his actin and myosin with better lactate recovery and synthetic organelles that act like "super-mitochondria". Oops, now his muscle cells consume more oxygen and he's getting out of breath. Oh well, we'll just fill him full of respirocytes so now his cells have way more oxygen to consume. How about shooting someone up with mystery gene transfection drugs that contain the RNA or DNA precursors to proteins that self-assemble entirely protein-based optoelectronics in someone's body out of amino acids and metal ions already inside someone? Very soon, they'll be able to do exactly that.




Bioinspired supramolecular chemistry can allow for a better interface between the semiconductive and biological worlds. In particular, simple peptide building blocks with the intrinsic ability to self-assemble into ordered nanostructures emerge as promising candidates (Fig. 1) (8, 9). The ample constituents, various morphologies, precise molecular structures, and biomolecular recognition endow the peptide self-assemblies with diversified physicochemical features. Integration with external semiconductive subunits, such as perylene imide moieties (1014), can yield self-assembled products with tunable morphologies and enhanced semiconductivity. In addition, with the intrinsic advantages of ease of preparation and flexibility of structure-function modulation, these bioinspired materials can be used in biotechnological and medical fields.

With the application of machine learning to biotech and de novo protein design, the conventional wisdom that synthetic biology stands just beyond the reach of our fingertips no longer applies. Sure, they don't know what every biological pathway does or what all the pleiotropic effects of turning one gene on or off are. Yet. Biological systems are complex, but they are not of infinite complexity. A lot of the papers I've seen deal with interfacing nanoparticles, nanowires, et cetera, with biology, in a biocompatible way, triggering no inflammation, such that cells don't even suspect these things are there. We're talking direct integration of nanometer-scale components with cells such that they're basically just another organelle, and if they're coated or doped with proteins, or if the payload also includes genetic material that permanently forces that cell to translate proteins that integrate with and shield the nanoparticles, then they basically would behave essentially like an artificial organelle, or reversible catalyst, or whatever.

This is not just me throwing shit at a wall and seeing what sticks. There are papers describing exactly that.


Previous examples all involved free complexes which entered cells because of their hydrophobicity, enabling them to pass the cell membrane. Compartmentalization approaches have also been applied, although the number of examples is more limited. Gold nanoparticles were coated with a hydrophobic layer to enable encapsulation of either [Cp*Ru(cod)Cl] or 1,1′- bis(diphenylphosphino) ferrocene)palladium(II)dichloride) (Figure 2).24 The periphery of the coating was functionalized with dimethylbenzylammonium groups, binding partners of cucurbituril[7]. Complexation with cucurbituril[7] led to gating of the catalytic activity by making the catalyst inaccessible to the substrate. This was demonstrated in HeLa cells treated with the gated ruthenium containing nanoparticles. Addition of alloc-R110 only showed background signal, whereas bright fluorescence was observed upon subsequent treatment with 1-adamantylamine, a competitive binding agent of cucurbituril[7] (Table 1, entry 3). These nanoparticles were also successfully applied in HeLa cells in a prodrug strategy for the in situ activation of alloc-caged doxorubicin and the (propargyl protected) chemotherapeutic agent 5-fluorouracil (5-FU) (Table 1, entry 3, 18).24, 54

cbic202000850-fig-0002-m.jpg

In this experiment, they coated gold nanoparticles with a hydrophobic layer and then complexed them with cucurbituril and introduced them into HeLa cells. Upon adding 1-adamantylamine, it bound to the cucurbituril and disinhibited the effect of the nanoparticle, allowing the gold catalyst access to the intended substrate.

That's not the only one.


Subcellular compartmentalization of macromolecules increases flux and prevents inhibitory interactions to control biochemical reactions. Inspired by this functionality, we sought to build designer compartments that function as hubs to regulate the flow of information through cellular control systems. We report a synthetic membraneless organelle platform to control endogenous cellular activities through sequestration and insulation of native proteins. We engineer and express a disordered protein scaffold to assemble micron-size condensates and recruit endogenous clients via genomic tagging with high-affinity dimerization motifs. By relocalizing up to 90% of targeted enzymes to synthetic condensates, we efficiently control cellular behaviors, including proliferation, division and cytoskeletal organization. Further, we demonstrate multiple strategies for controlled cargo release from condensates to switch cells between functional states. These synthetic organelles offer a powerful and generalizable approach to modularly control cell decision-making in a variety of model systems with broad applications for cellular engineering.

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This is what biodigital convergence is all about. It's about treating biochemical signaling processes in molecular biology as though they were like programmable logic controllers, and you can just add or remove whatever components you want, designing entirely new types of cells and new types of tissues that never existed in nature and could have never evolved on their own, and which incorporate biochemical, optical, and electronic computational substrates directly into their architecture, and interact with nanoparticles to form machine-cell interfaces.

You probably think I'm joking, but I'm not. They are implementing literal Boolean logic in biocompatible systems.


Green developed Toehold Switches with Yin and began the present study as a Postdoctoral Fellow in Yin's team. He was also mentored by Collins with whom he helped develop paper-based diagnostics for different viruses using Toehold Switches. Green is now Assistant Professor at the Biodesign Institute and the School of Molecular Sciences at Arizona State University where he continued experiments with his graduate student and co-author Duo Ma.

"Once we had worked out how to use Toehold Switches and RNA molecules to encode the basic logic operations – AND, OR, and NOT – we were able to condense this functionality within a carefully designed molecule that we call a gate RNA. Use of a gate RNA makes the Ribocomputing Devices much more genetically compact and helps with scaling up the circuits so that the cells can make more complex decisions," added Green.

"We even successfully deployed two independent gate RNAs expressing different fluorescent proteins in a bacterial cell, opening up the possibility to engineer multiple gate RNAs to work within the same cell at the same time towards constructing whole-cell biosensors. In addition, we believe that tried-and-tested Ribocomputing Devices can be easily shuttled to different microorganisms," said Jongmin Kim, Ph.D., co-first author on the study and a Postdoctoral Fellow working with Yin.

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Here, we designed and realized the nanoparticle-based VNA (NVNA) for molecular computing on the LNT platform. To create a stored-program device for the facile programming on a molecular computing platform, we applied the VNA with nanoparticles by incorporating the concept of memory that stores molecular information (Fig. 1A). The stored information is then processed once the instruction codes are introduced from a user. We separate hardware and software, and the conceptual separation contributes to the modularity and scalability of information processing in LNT in that only "updating" software allows a user to perform multiple computational tasks without fabricating a device every single time.

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Now, think back to those videos I embedded up there, particularly the ones with James Giordano and Charles Morgan holding speeches at West Point's Modern War Institute, especially the one with Charles Morgan talking about editing people's memories by injecting them with designer cells. There is extensive funding of this sort of research from DARPA (and eventually, ARPA-H), as well as shady NGOs like Wellcome Leap.


In addition to his long-standing leadership role at Illumina, Jay Flatley is also a "digital member" of the World Economic Forum as well as the lead independent director of Zymergen, a WEF "tech pioneer" company that is "rethinking biology and reimagining the world." Flatley, who has also attended several Davos meetings, has addressed the WEF on the "promise of precision [i.e., gene-specific] medicine." At another WEF panel meeting, Flatley, alongside UK Health Secretary Matt Hancock, promoted the idea of making genomic sequencing of babies at birth the norm, claiming it had "the potential to shift the healthcare system from reactive to preventative." Some at the panel called for the genomic sequencing of infants to eventually become mandatory.

In summary, if this tech is used to make supermen, you won't even notice that they're augmented. It won't be like Cyberpunk 2077 where people have obviously mechanical limbs or anything like that. Instead, they'll have custom cells and tissues, perhaps even entirely new scratch-made organs, filled with nanoparticles and artificial tissue scaffolds to direct the actions of their cells artificially, but they will outwardly look exactly like anyone else.

Now, how long do you think it'll be before this crosses over into the realm of engineering humans into biologically-restricted castes from which there is no upward mobility, Brave New World-style? The ruling class already view us as livestock. There are no effective regulatory or bioethical barriers keeping them from doing this.



Yes, the tech to do this is in a primitive state. That's no excuse not to scrutinize it. In fact, now is the best time for watchdog groups to form and make sure that this technology is not used for extremely unethical purposes, because in ten years, these technologies won't be confined to laboratories. They'll be in consumer products, drugs, and medical implants.
 

Cherico

Well-known member
Human beings always insist on learning everything the fucking hard way.

My money.

There are going to be a whole lot of varables you simply cant account for, and that it will all end in tears and blood shed and when its all over western civilization will go hard traditionalist and inovation will become a dirty word once more.
 

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