China Wuhan Virus Pandemic

Iconoclast

Iconoclast

Perpetually Angry
Obozny
DarthOne said:
DEATHWALKER!
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We are officially at levels of Jha’dur that shouldn’t even be physically possible.

www.scientificamerican.com

Billionaires Bankroll Cell Rejuvenation Tech as the Latest Gambit to Slow Aging

Start-ups bet that carefully controlled cell reprogramming may lead to age reversal, but hurdles remain
www.scientificamerican.com www.scientificamerican.com

Sebastiano's team showed that mRNA-based expression of the four Yamanaka factors plus two accessory factors (LIN28 and NANOG) to boost reprogramming efficiency could reverse epigenetic and inflammatory signatures and restore regenerative potential in a range of cell types from aged people—cultured fibroblasts, endothelial cells and chondrocytes. "We have seen this now across almost 20 different human cell types," Sebastiano says.
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Scottty

Scottty

Well-known member
Founder
*THASF* said:
We are officially at levels of Jha’dur that shouldn’t even be physically possible.

www.scientificamerican.com

Billionaires Bankroll Cell Rejuvenation Tech as the Latest Gambit to Slow Aging

Start-ups bet that carefully controlled cell reprogramming may lead to age reversal, but hurdles remain
www.scientificamerican.com www.scientificamerican.com
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Skimming through there, I'm seeing another "We're going to treat people with lipid-based nanoparticles containing mRNA, and that mRNA is going to go only where we intend it to go and do only what we intend it to do."
 
M

Marduk

Well-known member
Moderator
Staff Member
Rocinante said:
He was saying 1 in 35 with myocardial symptoms the other day.

Holy. Fucking. Shit. This is bad.
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Yup. Bad enough to get sued to shit if no political shenanigans shield the culprits, not bad enough to vindicate all the doomers and conspiracy theorists who were talking about 30\60\80\99% killshot, who in turn get used by media as the strawman to discredit the more reasonable dissenters from "safe and effective" narrative.
 
Rocinante

Rocinante

Russian Bot
Founder
Marduk said:
Yup. Bad enough to get sued to shit if no political shenanigans shield the culprits, not bad enough to vindicate all the doomers and conspiracy theorists who were talking about 30\60\80\99% killshot, who in turn get used by media as the strawman to discredit the more reasonable dissenters from "safe and effective" narrative.
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I had decided to take a "wait and see" approach because I don't trust big pharma or the government, and both them working together scared the shit out of me.

I waited. I saw. I am seeing more now. 1 in 35 is an insanely large number. I wonder how far their federal protections go, because this is fucked up.

I was expecting like 1 in 1000. Which was still bad enough for me not to take it. 1 in 35 is astronomical by comparison.
 
Iconoclast

Iconoclast

Perpetually Angry
Obozny
Rocinante said:
I had decided to take a "wait and see" approach because I don't trust big pharma or the government, and both them working together scared the shit out of me.

I waited. I saw. I am seeing more now. 1 in 35 is an insanely large number. I wonder how far their federal protections go, because this is fucked up.

I was expecting like 1 in 1000. Which was still bad enough for me not to take it. 1 in 35 is astronomical by comparison.
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I got into an argument with PainRack about this on Discord. He insisted that the vaccine produced Spike proteins that were then busted up into small fragments and presented by MHC, and that it didn't "cover cells in whole Spike protein willy-nilly". He was actually completely wrong about that. The mRNA vaccines absolutely do decorate cells in whole Spike.

www.ncbi.nlm.nih.gov

Antigen Presentation of mRNA-Based and Virus-Vectored SARS-CoV-2 Vaccines

Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 2019 (COVID-19), which has reached pandemic proportions. A number of effective vaccines have been produced, including mRNA vaccines and viral vector ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The end product in host cells expressing these mRNA vaccines is a surface-exposed, membrane-anchored, glycosylated, and trimerized Spike protein resembling the 3-D structure of the native viral Spike protein, to the extent that it interacts with its cognate receptor, hACE2 [22].
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This is why biodistribution studies are so important. Lipid nanoparticle delivery of mRNA is not specific to deltoid muscle tissue in the shoulder. LNPs have historically been investigated as a means of delivering Alzheimer's drugs across the blood-brain barrier, because they go fucking everywhere and transfect fucking everything.

Immune cells come along and see heart muscle cells decorated in whole Spike, and they don't care that they're your precious heart muscle cells. The reaction of your white blood cells will be something along these lines:



The whole concept of presenting antigens to the immune system on the surfaces of human cells is completely fucking bankrupt. This same exact shit would happen with any viral protein produced by LNP-delivered mRNA or Adenovirus-vector-delivered DNA, not just Spike. They are enticing the immune system to attack healthy tissue in a manner similar to transplant rejection, making your own heart muscle cells look like foreign bodies.

Panagis Polykretis pointed this out in a letter over a year ago.

www.ncbi.nlm.nih.gov

Role of the antigen presentation process in the immunization mechanism of the genetic vaccines against COVID‐19 and the need for biodistribution evaluations

www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

In conclusion, it is essential to underline that every human cell that intakes the LNPs and translates the viral protein (in case of the mRNA vaccines), or that gets infected by the adenovirus and expresses and translates the viral protein (in case of the adenovirus‐based vaccines), is inevitably recognized as a threat by the immune system and killed (Figure 1). There are no exceptions to this mechanism. The severity of the resulting damage and the consequences for health depend on the quantity of the cells involved, on the type of tissue and on the strength of the following autoimmune reaction. For instance, if the mRNA contained in the LNPs would get internalized by cardiac myocytes, and such cells would produce the spike protein, the resulting inflammation would likely lead to the necrosis of the myocardium, with an extent proportional to the number of involved cells.
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The original goal of DARPA's ADEPT: PROTECT program was to develop an mRNA-based mAb therapy against Chikungunya.



www.nature.com

A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus - Nature Medicine

An mRNA-based therapeutic can drive expression of a functional antibody in humans at levels capable of neutralizing Chikungunya virus ex vivo.
www.nature.com www.nature.com

Chikungunya virus (CHIKV) infection causes acute disease characterized by fever, rash and arthralgia, which progresses to severe and chronic arthritis in up to 50% of patients. Moreover, CHIKV infection can be fatal in infants or immunocompromised individuals and has no approved therapy or prevention. This phase 1, first-in-human, randomized, placebo-controlled, proof-of-concept trial conducted from January 2019 to June 2020 evaluated the safety and pharmacology of mRNA-1944, a lipid nanoparticle-encapsulated messenger RNA encoding the heavy and light chains of a CHIKV-specific monoclonal neutralizing antibody, CHKV-24 (NCT03829384). The primary outcome was to evaluate the safety and tolerability of escalating doses of mRNA-1944 administered via intravenous infusion in healthy participants aged 18–50 years. The secondary objectives included determination of the pharmacokinetics of mRNA encoding for CHKV-24 immunoglobulin heavy and light chains and ionizable amino lipid component and the pharmacodynamics of mRNA-1944 as assessed by serum concentrations of mRNA encoding for CHKV-24 immunoglobulin G (IgG), plasma concentrations of ionizable amino lipid and serum concentrations of CHKV-24 IgG. Here we report the results of a prespecified interim analysis of 38 healthy participants who received intravenous single doses of mRNA-1944 or placebo at 0.1, 0.3 and 0.6 mg kg−1, or two weekly doses at 0.3 mg kg−1. At 12, 24 and 48 h after single infusions, dose-dependent levels of CHKV-24 IgG with neutralizing activity were observed at titers predicted to be therapeutically relevant concentrations (≥1 µg ml−1) across doses that persisted for ≥16 weeks at 0.3 and 0.6 mg kg−1 (mean t1/2 approximately 69 d). A second 0.3 mg kg−1 dose 1 week after the first increased CHKV-24 IgG levels 1.8-fold. Adverse effects were mild to moderate in severity, did not worsen with a second mRNA-1944 dose and none were serious. To our knowledge, mRNA-1944 is the first mRNA-encoded monoclonal antibody showing in vivo expression and detectable ex vivo neutralizing activity in a clinical trial and may offer a treatment option for CHIKV infection. Further evaluation of the potential therapeutic use of mRNA-1944 in clinical trials for the treatment of CHIKV infection is warranted.
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The dynamics of producing monoclonal antibodies in vivo and then having those cells export those antibodies are completely different from having cells produce toxic viral proteins in vivo and then having those foreign proteins anchor into the surfaces of cells with a transmembrane domain. The delivery mechanism is the same, but the product the cell spits out is not even remotely the same, pharmacologically-speaking.

These mRNA and viral vector vaccines are pure hubris, or something worse. Tools of deliberate murder, more like.
 
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